The surrounding rock of water diversion tunnels in high-head pumped storage power stations often suffers from seepage failure or instability. Focusing on a high-head pumped storage power station in western Sichuan, in-situ stress measurements by hydraulic fracturing method and high-pressure water injection tests were conducted at key locations in the project. Through statistical analysis of measured stress and combined with geological conditions of surrounding rock, the stress field distribution characteristics of different tunnel sections of the power station are studied. The stress value mainly varies with burial depth, but is affected by local differences in geological conditions, showing differentiation in the diversion tunnel and underground powerhouse area. The stress direction is greatly affected by the terrain of the valley, and overall it tends to be closer to the direction of the lower reservoir valley. Considering factors such as the overall layout of the hub, the orientation of dominant structural planes, and the direction of maximum in-situ stress, a reasonable plan for the layout of the powerhouse axis were proposed. Based on the statistics of rock mass permeability test, the permeability stability and hydraulic jacking resistance ability of surrounding rock of high-pressure diversion tunnel are evaluated. According to the relevant criteria, targeted suggestions have been provided for the surrounding rock lining schemes of different tunnel sections.